Cell News 01/2017
17
Mechanisms and mechanics of epidermal stem cell fate
regulation
Sara A. Wickström
AWARD WINNERS
Max Planck Research Group Leader
Max Planck Institute for Biology of Ageing
/
Our research aims to uncover how complex but stereotyped
tissues are formed, maintained and regenerated through
local growth, differentiation and remodeling. To decipher this
fundamental question we need to understand how single cell
behaviors are coordinated on the population level and how
population-level dynamics is coupled to tissue architecture.
Uncovering these regulatory principles will further facilitate
development of stem cell (SC) therapies and effective treat-
ments against cancers.
As a self-renewing organ maintained by distinct stem cell
populations, the epidermis represents an outstanding, clinically
highly relevant research paradigm to address these questions.
We apply mouse genetics and molecular cell biology, combined
with state-of-the art biological imaging, biophysics, biochem-
istry and theoretical approaches to study stem regulation and
tissue homeostasis/aging in this system. In my presentation
I will discuss our recent research on stem cell-niche interac-
tions in cell fate decisions and reprogramming, and the role of
mechanical forces in these processes.
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