Cell News 02/2018
17
MEETING REPORT
the major issues being biomechanics, including biopolymers,
networks, rheology, cytoskeleton and cell shape. Moreover, forces,
motion, adhesion, cell motility, macromolecular assembly as well
as molecular motors have established their central importance
as fundamental concepts underpinning the meeting. In general
terms, oncology and imaging techniques were uniting themes for
many of the presentations.
In line with these topics, the 2017 symposium included the ses-
sions outlined below including a poster session with 30 presenters.
The presentations ranged from "classical" Physics of Cancer topics
as defined above, to innovative instrumentation (e.g. light-sheet
microscopy and real-time deformability cytometry) to new clinical
approaches (autologous CAR-NK immunotherapy) and even new
ways to view cancer through creative analogies to eye disorders
and financial markets. The breadth of topics reflected the broad-
ening reach of physical science into many different aspects of the
oncological sciences. In this way the meeting is a reflection of
cancer science in general, keeping a strong focus on the funda-
mentals, inventing new ways to measure and view the problem,
and finally using this knowledge to create new solutions.
The following list with the speakers and the titles of their talks will
give an expression on the variety of contributions, which we will
not summarize here, as most of the work was unpublished.
Session I: Cell Migration & Invasion
Ingo Bechmann
(University of Leipzig, Germany) Slice Cultures as
Tool to Study Cancers in Vitro
Mohit Kumar Jolly
(Rice University, USA) Hybrid Epithelial/
Mesenchymal Phenotype (E/M) – a ‘Metastatic Sweet Spot’
Katarina Wolf
(Radboud Institute for Molecular Life Sciences,
The Netherlands) Control of Cancer Cell Invasion by Nuclear
Deformability
Sagar Regmi
(Nanyang Technological University, Singapore) High
Shear Stresses under Exercise Condition Destroy Circulating Tumor
Cells in a Microfluidic System
Tobias Zech
(University of Liverpool, GB) Matrix Adhesion Site
Function in Polarised Invasive Migration
Special Focus Session: Collective Cell Behavior
Stephan Grill
(Technical University Dresden, Germany) Control of
Mechanochemical Self-Organization during Cell Polarization
Andrew Clark
(Institute Curie, France) Mechanisms of Collective
Cell Migration and the Influence of the Microenvironment
Jae Hun Kim
(Harvard T.H. Chan School of Public Health, USA)
Unjamming and Cell Shape Changes in Breast Cancer
Daniel Sussman
(Syracuse University, USA) Tissue Surface Tension
in Simple Models of Dense Biological Tissues
Session II: Biomechanics
Miriam Dietrich
(Ludwig-Maximilians-University, Germany)
Guiding 3D Cell Migration inside Strained Synthetic Hydrogel
Micro-Structures
Kay Gottschalk
(University of Ulm, Germany) The Weakness of
Senescent Fibroblasts
Jan Lammerding
(Cornell University, USA) Squish and Squeeze –
the Role of the Nucleus and Lamins in Cancer Metastasis
Ben Fabry
(Friedrich-Alexander University of Erlangen-Nuremberg,
Germany) Interactions of Natural Killer Cells with Cancer Cells in a
3-D Environment
Nastaran Zahir
(National Cancer Institute, USA) Integrating Scales
in Cancer Mechanobiology: The NCI Physical Sciences – Oncology
Network
Ulf-Dietrich
Braumann (Fraunhofer Institute for Cell Therapy and
Immunology, Germany) Light Sheet Fluorescence Microscopy:
Advantages for Living Specimens
Ulrike Köhl
(Hannover Medical School, Germany) From “CAR T
Cells” to CAR Expressing NK Cells for Cancer Retargeting
Pascal Silberzan
(Institut Curie Paris, France) Collectively
Emerging Nematic Order in Populations of Fibroblasts
Sebastian Schmidt
(University of Maryland, USA) Disrupting
Chemotaxis Using Contact Guidance of Nanotopography
Session III: Cellular Organization
Adrian Fessel
(University of Bremen, Germany) Non-Linear
Compliance of Elastic Layers to Indentation
Joachim Spatz
(Max Planck Institute for Medical Research and
Mohit Kumar Jolly on homeostasis.
Katarina Wolf getting started for her presentation.
