plants live perfectly well without them. And one may further
wonder why some differentiated animal cells that no longer
divide, like neurons or leucocytes, retain a centrosome
while others such as myotubes eliminate centrosomes? Like-
wise, why do some resting cells grow a primary cilium
whereas others never do, despite having the appendages on
the mother centriole that could enable them to do so? Can
we propose a unified functional framework in which all
these differences would make sense? Cell polarity and its
transmission to daughter cells through division in somatic
lineages, or from the male gamete to the zygote through fer-
tilization in most animal species, come across as a broad
unifying theme that encompasses the numerous functions
in which the centrosome can be involved.
In closing, let us reiterate that one cannot hope to get at a
comprehensive understanding of centrosome function in
diverse systems without a comparative analysis of the cellular
economy resulting from the survival strategy of each organism.
This is what makes the study of centrosomes both important
and attractive. We trust that this Theme Issue will both provide
a snapshot of the progress to date and fuel advances for the
years to come. Hopefully, the next collective coverage will
have answers for many of the questions that are open in 2014
and undoubtedly come up with new ones!
Acknowledgements.
We thank members of our laboratories and col-
leagues around the world for interesting discussions over the years.
We are grateful also to Fernando R. Balestra and Paul Guichard for
useful comments on the manuscript and help in preparing the
figure. We wish to thank the following people who acted as referees
on the papers within this issue: Miguel Angel Alonso, Kathryn
Anderson, Renata Basto, Mo´ nica Bettencourt-Dias, Trisha Davis,
Stefan Duensing, Susan Dutcher, Andrew Fry, Joseph Gall, David
Glover, Keith Gull, Edward Hinchcliffe, Andrew Jackson, Alexey
Khodjakov, Akatsuki Kimura, Michael Knop, Ryoko Kuriyama,
James Maller, Thomas Mayer, Andrea McClatchey, Nicolas Minc,
Ciaran Morrison, Kevin O’Connell, Judith Paridaen, Chad Pearson,
Laurence Pelletier, Franck Perez, Claude Prigent, Jordan Raff, Gre-
gory Rogers, Jeffrey Salisbury, Songhai Shi, Yukiko Yamashita and
Manuela Zaccolo.
Funding statement.
M.B. is supported by CNRS and Institut Curie. Work
on centrosome duplication in the laboratory of P.G. is supported by a
grant from the ERC (AdG 340227).
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