Cell News | Issue 01, 2015 - page 21

21
Cell News 1/2015
Research news
alpha(5)beta(1) integrins promotes early fibronectin fibrillogenesis. J Cell Biol 148, 1075-
1090.
Radovanac, K., Morgner, J., Schulz, J.N., Blumbach, K., Patterson, C., Geiger, T., Mann, M.,
Krieg, T., Eckes, B., Fässler, R., and Wickström, S.A. (2013). Stabilization of integrin-linked
kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic
response. EMBO J 32, 1409-1424.
Sakai, T., Larsen, M., and Yamada, K.M. (2003a). Fibronectin requirement in branching mor-
phogenesis. Nature 423, 876-881.
Sakai, T., Li, S., Docheva, D., Grashoff, C., Sakai, K., Kostka, G., Braun, A., Pfeifer, A., Yurchen-
co, P.D., and Fässler, R. (2003b). Integrin-linked kinase (ILK) is required for polarizing the
epiblast, cell adhesion, and controlling actin accumulation. Genes Dev 17, 926-940.
Schiller, H.B., and Fässler, R. (2013). Mechanosensitivity and compositional dynamics of
cell-matrix adhesions. EMBO reports 14, 509-519.
Schwarzbauer, J.E., and DeSimone, D.W. (2011). Fibronectins, their fibrillogenesis, and in vivo
functions. Cold Spring Harb Perspect Biol 3.
Sechler, J.L., Cumiskey, A.M., Gazzola, D.M., and Schwarzbauer, J.E. (2000). A novel RGD-
independent fibronectin assembly pathway initiated by alpha4beta1 integrin binding to the
alternatively spliced V region. Journal of cell science 113, 1491-1498.
Stanchi, F., Grashoff, C., Nguemeni Yonga, C.F., Grall, D., Fässler, R., and Van Obberghen-
Schilling, E. (2009). Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamen-
tal role for the ILK kinase domain in the late stages of focal-adhesion maturation. Journal
of cell science 122, 1800-1811.
Stiegler, A.L., Grant, T.D., Luft, J.R., Calderwood, D.A., Snell, E.H., and Boggon, T.J. (2013). Pu-
rification and SAXS analysis of the integrin linked kinase, PINCH, parvin (IPP) heterotrimeric
complex. PLoS One 8, e55591.
Tomasek, J.J., Gabbiani, G., Hinz, B., Chaponnier, C., and Brown, R.A. (2002). Myofibroblasts
and mechano-regulation of connective tissue remodelling. Nature reviews. Molecular cell
biology 3, 349-363.
Vi, L., de Lasa, C., DiGuglielmo, G.M., and Dagnino, L. (2011). Integrin-linked kinase is re-
quired for TGF-beta1 induction of dermal myofibroblast differentiation. J Invest Dermatol
131, 586-593.
Vicente-Manzanares, M., and Horwitz, A.R. (2011). Adhesion dynamics at a glance. Journal
of cell science 124, 3923-3927.
Vouret-Craviari, V., Boulter, E., Grall, D., Matthews, C., and Van Obberghen-Schilling, E.
(2004). ILK is required for the assembly of matrix-forming adhesions and capillary morpho-
genesis in endothelial cells. Journal of cell science 117, 4559-4569.
Watt, F.M., and Fujiwara, H. (2011). Cell-extracellular matrix interactions in normal and
diseased skin. Cold Spring Harb Perspect Biol 3.
Wennerberg, K., Lohikangas, L., Gullberg, D., Pfaff, M., Johansson, S., and Fassler, R. (1996).
Beta 1 integrin-dependent and -independent polymerization of fibronectin. J Cell Biol 132,
227-238.
Wickström, S.A., Lange, A., Hess, M.W., Polleux, J., Spatz, J.P., Kruger, M., Pfaller, K., Lam-
bacher, A., Bloch, W., Mann, M., Huber, L.A., and Fässler, R. (2010b). Integrin-linked kinase
controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev
Cell 19, 574-588.
Wickström, S.A., Lange, A., Montanez, E., and Fässler, R. (2010a). The ILK/PINCH/parvin com-
plex: the kinase is dead, long live the pseudokinase! EMBO J 29, 281-291.
Wickström, S.A., Radovanac, K., and Fässler, R. (2011). Genetic analyses of integrin signaling.
Cold Spring Harb Perspect Biol 3.
Wynn, T.A., and Ramalingam, T.R. (2012). Mechanisms of fibrosis: therapeutic translation for
fibrotic disease. Nature Medicine 18, 1028-1040.
Yang, J.T., Bader, B.L., Kreidberg, J.A., Ullman-Cullere, M., Trevithick, J.E., and Hynes, R.O.
(1999). Overlapping and independent functions of fibronectin receptor integrins in early
mesodermal development. Developmental biology 215, 264-277.
Zamir, E., and Geiger, B. (2001). Molecular complexity and dynamics of cell-matrix adhesi-
ons. Journal of cell science 114, 3583-3590.
Zamir, E., Katz, M., Posen, Y., Erez, N., Yamada, K.M., Katz, B.Z., Lin, S., Lin, D.C., Bershadsky,
A., Kam, Z., and Geiger, B. (2000). Dynamics and segregation of cell-matrix adhesions in
cultured fibroblasts. Nature cell biology 2, 191-196.
Zervas, C.G., Gregory, S.L., and Brown, N.H. (2001). Drosophila integrin-linked kinase is re-
quired at sites of integrin adhesion to link the cytoskeleton to the plasma membrane. J Cell
Biol 152, 1007-1018.
ORCA-Flash4.0 LT
The benefits of sCMOS technology at
the price of a CCD.
30 frames/second at 4.2 megapixel resolution
USB 3.0 connectivity
Robust synchronisation
W-VIEW Mode - independent exposure of each half
of the sensor for two-colour imaging
The perfect partners for dual colour imaging
W-VIEW GEMINI
Optics for simultaneous dual wavelength
imaging by one camera.
Matched to the performance of Gen II sCMOS cameras
Chromatically corrected
User-defined filter combinations
Easily aligned, optically and mechanically stable
NEW
Hamamatsu_Swiss_189x129_Layout 1 16/01/2015 09:06 Page 1
1...,11,12,13,14,15,16,17,18,19,20 22,23,24,25,26,27,28,29,30
Powered by FlippingBook