Cell News | Issue 01, 2015 - page 15

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Cell News 1/2015
Remodeling. PLoS pathogens 10, e1004351.
Bos, J.L., Rehmann, H., and Wittinghofer, A. (2007). GEFs and GAPs: critical elements in the
control of small G proteins. Cell 129, 865-877.
Dangl, J.L., Horvath, D.M., and Staskawicz, B.J. (2013). Pivoting the plant immune system
from dissection to deployment. Science 341, 746-751.
Eitel, J., Krull, M., Hocke, A.C., N'Guessan, P.D., Zahlten, J., Schmeck, B., Slevogt, H., Hippen-
stiel, S., Suttorp, N., and Opitz, B. (2008). Beta-PIX and Rac1 GTPase mediate trafficking and
negative regulation of NOD2. J Immunol 181, 2664-2671.
Eitel, J., Meixenberger, K., van Laak, C., Orlovski, C., Hocke, A., Schmeck, B., Hippenstiel, S.,
N'Guessan, P.D., Suttorp, N., and Opitz, B. (2012). Rac1 regulates the NLRP3 inflammasome
which mediates IL-1beta production in Chlamydophila pneumoniae infected human mono-
nuclear cells. PloS one 7, e30379.
Freeman, S.A., Jaumouille, V., Choi, K., Hsu, B.E., Wong, H.S., Abraham, L., Graves, M.L.,
Coombs, D., Roskelley, C.D., Das, R., Grinstein, S., and Gold, M.R. (2015). Toll-like receptor li-
gands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement
of the receptor. Nature communications 6, 6168.
Friebel, A., Ilchmann, H., Aepfelbacher, M., Ehrbar, K., Machleidt, W., and Hardt, W.D. (2001).
SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the
host cell. The Journal of biological chemistry 276, 34035-34040.
Fukazawa, A., Alonso, C., Kurachi, K., Gupta, S., Lesser, C.F., McCormick, B.A., and Reinecker,
H.C. (2008). GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella
effectors. PLoS pathogens 4, e1000228.
Hall, A. (2012). Rho family GTPases. Biochemical Society transactions 40, 1378-1382.
Kawai, T., and Akira, S. (2011). Toll-like receptors and their crosstalk with other innate re-
ceptors in infection and immunity. Immunity 34, 637-650.
Keestra, A.M., Winter, M.G., Auburger, J.J., Frassle, S.P., Xavier, M.N., Winter, S.E., Kim, A.,
Poon, V., Ravesloot, M.M., Waldenmaier, J.F., Tsolis, R.M., Eigenheer, R.A., and Baumler, A.J.
(2013). Manipulation of small Rho GTPases is a pathogen-induced process detected by
NOD1. Nature 496, 233-237.
Kufer, T.A. (2008). Signal transduction pathways used by NLR-type innate immune recep-
tors. Mol Biosyst 4, 380-386.
Kufer, T.A., Kremmer, E., Adam, A.C., Philpott, D.J., and Sansonetti, P.J. (2008). The pattern-
recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial inter-
action. Cellular microbiology 10, 477-486.
Kustermans, G., El Mjiyad, N., Horion, J., Jacobs, N., Piette, J., and Legrand-Poels, S. (2008a).
Actin cytoskeleton differentially modulates NF-kappaB-mediated IL-8 expression in myelo-
monocytic cells. Biochemical pharmacology 76, 1214-1228.
Kustermans, G., Piette, J., and Legrand-Poels, S. (2008b). Actin-targeting natural com-
pounds as tools to study the role of actin cytoskeleton in signal transduction. Biochemical
pharmacology 76, 1310-1322.
Legrand-Poels, S., Kustermans, G., Bex, F., Kremmer, E., Kufer, T.A., and Piette, J. (2007).
Modulation of Nod2-dependent NF-kappaB signaling by the actin cytoskeleton. Journal of
cell science 120, 1299-1310.
Maekawa, T., Kufer, T.A., and Schulze-Lefert, P. (2011). NLR functions in plant and animal
immune systems: so far and yet so close. Nature immunology 12, 817-826.
Man, S.M., Ekpenyong, A., Tourlomousis, P., Achouri, S., Cammarota, E., Hughes, K., Rizzo, A.,
Ng, G., Wright, J.A., Cicuta, P., Guck, J.R., and Bryant, C.E. (2014). Actin polymerization as a
key innate immune effector mechanism to control Salmonella infection. Proceedings of the
National Academy of Sciences of the United States of America.
Mizuno, K. (2013). Signaling mechanisms and functional roles of cofilin phosphorylation
and dephosphorylation. Cellular signalling 25, 457-469.
Mullins, R.D. (2000). How WASP-family proteins and the Arp2/3 complex convert intracellu-
lar signals into cytoskeletal structures. Current opinion in cell biology 12, 91-96.
Olayioye, M.A., Barisic, S., and Hausser, A. (2013). Multi-level control of actin dynamics by
protein kinase D. Cellular signalling 25, 1739-1747.
Pollard, T.D. (1990). Actin. Current opinion in cell biology 2, 33-40.
Ren, M., Feng, H., Fu, Y., Land, M., and Rubin, C.S. (2009). Protein kinase D is an essential
regulator of C. elegans innate immunity. Immunity 30, 521-532.
Rotty, J.D., Wu, C., and Bear, J.E. (2013). New insights into the regulation and cellular func-
tions of the ARP2/3 complex. Nature reviews. Molecular cell biology 14, 7-12.
Rudolph, M.G., Weise, C., Mirold, S., Hillenbrand, B., Bader, B., Wittinghofer, A., and Hardt,
W.D. (1999). Biochemical analysis of SopE from Salmonella typhimurium, a highly efficient
guanosine nucleotide exchange factor for RhoGTPases. The Journal of biological chemistry
274, 30501-30509.
Schlumberger, M.C., and Hardt, W.D. (2005). Triggered phagocytosis by Salmonella: bacte-
rial molecular mimicry of RhoGTPase activation/deactivation. Curr Top Microbiol Immunol
291, 29-42.
Scott, R.W., and Olson, M.F. (2007). LIM kinases: function, regulation and association with
human disease. Journal of molecular medicine 85, 555-568.
Sept, D., and McCammon, J.A. (2001). Thermodynamics and kinetics of actin filament nuc-
leation. Biophysical journal 81, 667-674.
Valencia-Gallardo, C.M., Carayol, N., and Tran Van Nhieu, G. (2015). Cytoskeletal mecha-
nics during Shigella invasion and dissemination in epithelial cells. Cellular microbiology
17, 174-182.
Authors
Angelika Hausser
studied technical Biology at the Universi-
ty of Stuttgart. She did her PhD with Klaus
Pfizenmaier at the Institute of Cell Biology
and Immunology in Stuttgart working on
the role of protein kinase D at the Golgi
compartment and continued with these
studies during her postdoc. Since 2003 she
leads the PKD signaling group at the Ins-
titute of Cell Biology and Immunology, University of Stuttgart.
Kornelia Ellwanger
studied technical Biology at the University
of Stuttgart. For her PhD thesis and post-
doc, she joined the Lab of Angelika Hausser
in 2004 where she works on
in vivo
models
to study protein kinase D function.
From April 2015 she will join the group of
Thomas Kufer, Department of Immunology
at the University of Hohenheim.
Thomas Kufer
studied Biology in Ludwig-Maximilian Uni-
versity in Munich. He did his PhD with Erich
Nigg at the MPI in Martinsried working on
mitotic kinases. For his postdoc he went to
the Institut Pasteur in Paris, France where
he worked with Dana Philipott and Philip-
pe Sansonetti on NOD1 and NOD2. He was
then an Independent Junior Group Leader
within the SFB670 at the Institute for Medical Microbiology,
Immunology and Hygiene at the University of Cologne. Since
October 2014 he heads the department of Immunology at the
University Hohenheim.
Universität Hohenheim, Institut für Ernährungsmedizin,
Fg. Immunologie, Fruwirth Str. 12, 70593 Stuttgart,
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