Cell News 4/2014
16
Research news
of embryonic axons. Cell 113, 657-670.
Gross, J.D. (2009). Acidic Ca
2+
stores, excitability, and cell patterning in
Dictyostelium
discoi-
deum. Eukaryot Cell 8, 696-702.
Harel, A., Bercovich, S., and Yarden, O. (2006). Calcineurin is required for sclerotial develop-
ment and pathogenicity of Sclerotinia sclerotiorum in an oxalic acid-independent manner.
Mol Plant Microbe Interact 19, 682-693.
Harren, K., Schumacher, J., and Tudzynski, B. (2012). The Ca
2+
/calcineurin-dependent signaling
pathway in the gray mold Botrytis cinerea: the role of calcipressin in modulating calcineurin
activity. PLoS One 7, e41761.
Heit, J.J. (2007). Calcineurin/NFAT signaling in the beta-cell: From diabetes to new therapeu-
tics. Bioessays 29, 1011-1021.
Horn, F., and Gross, J. (1996). A role for calcineurin in
Dictyostelium
discoideum development.
Differentiation 60, 269-275.
Juvvadi, P.R., Gehrke, C., Fortwendel, J.R., Lamoth, F., Soderblom, E.J., Cook, E.C., Hast, M.A.,
Asfaw, Y.G., Moseley, M.A., Creamer, T.P., and Steinbach, W.J. (2013). Phosphorylation of Cal-
cineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in
Aspergillus fumigatus. PLoS Pathog 9, e1003564.
Kim, H.S., Czymmek, K.J., Patel, A., Modla, S., Nohe, A., Duncan, R., Gilroy, S., and Kang, S.
(2012). Expression of the Cameleon calcium biosensor in fungi reveals distinct Ca(
2+
) signa-
tures associated with polarized growth, development, and pathogenesis. Fungal Genet Biol
49, 589-601.
Kothe, G.O., and Free, S.J. (1998). Calcineurin subunit B is required for normal vegetative
growth in Neurospora crassa. Fungal Genet Biol 23, 248-258.
Kraus, P.R., and Heitman, J. (2003). Coping with stress: calmodulin and calcineurin in model
and pathogenic fungi. Biochem Biophys Res Commun 311, 1151-1157.
Kubohara, Y., Arai, A., Gokan, N., and Hosaka, K. (2007). Pharmacological evidence that stalk
cell differentiation involves increases in the intracellular Ca(
2+
) and H(+) concentrations in
Dictyostelium
discoideum. Dev Growth Differ 49, 253-264.
Kujawski, S., Lin, W., Kitte, F., Börmel, M., Fuchs, S., Arulmozhivarman, G., Vogt, S., Theil, D.,
Zhang, Y., and Antos, C.L. (2014). Calcineurin regulates coordinated outgrowth of zebrafish
regenerating fins. Dev Cell 28, 573-587.
Kumar, R., Musiyenko, A., and Barik, S. (2005). Plasmodium falciparum calcineurin and its as-
sociation with heat shock protein 90: mechanisms for the antimalarial activity of cyclosporin
A and synergism with geldanamycin. Mol Biochem Parasitol 141, 29-37.
Kumar, R., Musiyenko, A., Oldenburg, A., Adams, B., and Barik, S. (2004). Post-translational
generation of constitutively active cores from larger phosphatases in the malaria parasite,
Plasmodium falciparum: implications for proteomics. BMC Mol Biol 5, 6.
Kume, K., Koyano, T., Kanai, M., Toda, T., and Hirata, D. (2011). Calcineurin ensures a link bet-
ween the DNA replication checkpoint and microtubule-dependent polarized growth. Nat Cell
Biol 13, 234-242.
Lawrence, M.C., Bhatt, H.S., Watterson, J.M., and Easom, R.A. (2001). Regulation of insulin
gene transcription by a Ca(
2+
)-responsive pathway involving calcineurin and nuclear factor of
activated T cells. Mol Endocrinol 15, 1758-1767.
Leclerc, C., Néant, I., and Moreau, M. (2011). Early neural development in vertebrates is also a
matter of calcium. Biochimie 93, 2102-2111.
Lee, J.I., Mukherjee, S., Yoon, K.H., Dwivedi, M., and Bandyopadhyay, J. (2013). The multiple
faces of calcineurin signaling in Caenorhabditis elegans: development, behaviour and aging.
J Biosci 38, 417-431.
Li, H., Rao, A., and Hogan, P.G. (2011). Interaction of calcineurin with substrates and targeting
proteins. Trends Cell Biol 21, 91-103.
Liberatore, C.M., and Yutzey, K.E. (2004). Calcineurin signaling in avian cardiovascular deve-
lopment. Dev Dyn 229, 300-311.
Liu, Y., Zhang, Y., Min, J., Liu, L.L., Ma, N.Q., Feng, Y.M., Liu, D., Wang, P.Z., Huang, D.D., Zhuang,
Y., and Zhang, H.L. (2010). Calcineurin promotes proliferation, migration, and invasion of small
cell lung cancer. Tumor Biol 31, 199-207.
Maden, M. (1982). Vitamin A and pattern formation in the regenerating limb. Nature 295,
672-675.
Malchow, D., Mutzel, R., and Schlatterer, C. (1996). On the role of calcium during chemotactic
signalling and differentiation of the cellular slime mould
Dictyostelium
discoideum. Int J Dev
Biol 40, 135-139.
Mallinson, J., Meissner, J., and Chang, K.C. (2009). Chapter 2. Calcineurin signaling and the
slow oxidative skeletal muscle fiber type. Int Rev Cell Mol Biol 277, 67-101.
Moreno, V.R., Agüero, F., Tekiel, V., and Sánchez, D.O. (2007). The Calcineurin A homologue
from Trypanosoma cruzi lacks two important regulatory domains. Acta Trop 101, 80-89.
Mukherjee, A., Morales-Scheihing, D., Gonzalez-Romero, D., Green, K., Taglialatela, G., and
Soto, C. (2010). Calcineurin inhibition at the clinical phase of prion disease reduces neuro-
degeneration, improves behavioral alterations and increases animal survival. PLoS Pathog 6.
Naderer, T., Dandash, O., and McConville, M.J. (2011). Calcineurin is required for Leishmania
major stress response pathways and for virulence in the mammalian host. Mol Microbiol 80,
471-480.
Neilson, J.R., Winslow, M.M., Hur, E.M., and Crabtree, G.R. (2004). Calcineurin B1 is essential
for positive but not negative selection during thymocyte development. Immunity 20, 255-266.
Prokisch, H., Yarden, O., Dieminger, M., Tropschug, M., and Barthelmess, I.B. (1997). Impairment
of calcineurin function in Neurospora crassa reveals its essential role in hyphal growth, mor-
phology and maintenance of the apical Ca
2+
gradient. Mol Gen Genet 256, 104-114.
Remillard, S.P., Lai, E.Y., Levy, Y.Y., and Fulton, C. (1995). A calcineurin-B-encoding gene ex-
pressed during differentiation of the amoeboflagellate Naegleria gruberi contains two introns.
Gene 154, 39-45.
Ruiz, A., Serrano, R., and Arino, J. (2008). Direct regulation of genes involved in glucose utili-
zation by the calcium/calcineurin pathway. J Biol Chem 283, 13923-13933.
Rusnak, F., and Mertz, P. (2000). Calcineurin: form and function. Physiol Rev 80, 1483-1521.
Sanglard, D., Ischer, F., Marchetti, O., Entenza, J., and Bille, J. (2003). Calcineurin A of Candida
albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol Micro-
biol 48, 959-976.
Sartain, C.V., and Wolfner, M.F. (2013). Calcium and egg activation in Drosophila. Cell Calcium
53, 10-15.
Sieber, M., and Baumgrass, R. (2009). Novel inhibitors of the calcineurin/NFATc hub - alterna-
tives to CsA and FK506? Cell Commun Signal 7, 25.
Siekierka, J.J., and Sigal, N.H. (1992). FK-506 and cyclosporin A: immunosuppressive mecha-
nism of action and beyond. Curr Opin Immunol 4, 548-552.
Singh, S., More, K.R., and Chitnis, C.E. (2013). Role of calcineurin and actin dynamics in regula-
ted secretion of microneme proteins in Plasmodium falciparum merozoites during erythrocyte
invasion. Cell Microbiol [Epub ahead of print].
Spires-Jones, T.L., Kay, K., Matsouka, R., Rozkalne, A., Betensky, R.A., and Hyman, B.T. (2011).
Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and den-
dritic spine density in healthy adult mouse brain. Neurosci Lett 487, 260-263.
Steinbach, W.J., Cramer, R.A., Perfect, B.Z., Asfaw, Y.G., Sauer, T.C., Najvar, L.K., Kirkpatrick,
W.R., Patterson, T.F., Benjamin, D.K., Heitman, J., and Perfect, J.R. (2006). Calcineurin controls
growth, morphology, and pathogenicity in Aspergillus fumigatus. Eukaryot Cell 5, 1091-1103.
Steinbach, W.J., Reedy, J.L., Cramer, R.A., Perfect, J.R., and Heitman, J. (2007). Harnessing cal-
cineurin as a novel anti-infective agent against invasive fungal infections. Nat Rev Microbiol
5, 418-430.
Sun, L., Blair, H.C., Peng, Y., Zaidi, N., Adebanjo, O.A., Wu, X.B., Wu, X.Y., Iqbal, J., Epstein, S., Abe,
E., Moonga, B.S., and Zaidi, M. (2005). Calcineurin regulates bone formation by the osteoblast.
Proc Natl Acad Sci U S A 102, 17130-17135.
Thewes, S. (2014). Calcineurin-Crz1 signaling in lower eukaryotes. Eukaryot Cell 13, 694-705.
Thewes, S., Schubert, S.K., Park, K., and Mutzel, R. (2014). Stress and development in
Dictyo-
stelium
discoideum: the involvement of the catalytic calcineurin A subunit. J Basic Microbiol
54, 607-613.
Todo, S., Demetris, A.J., Ueda, Y., Imventarza, O., Okuda, K., Casavilla, A., Cemaj, S., Ghalab, A.,
Mazzaferro, V., and Rhoe, B.S. (1987). Canine kidney transplantation with FK-506 alone or in
combination with cyclosporine and steroids. Transplant Proc 19, 57-61.
Tsai, H.C., and Chung, K.R. (2014). Calcineurin phosphatase and phospholipase C are required
for developmental and pathological functions in the citrus fungal pathogen Alternaria alter-
nata. Microbiology 160, 1453-1465.
Viaud, M., Brunet-Simon, A., Brygoo, Y., Pradier, J.M., and Levis, C. (2003). Cyclophilin A and
calcineurin functions investigated by gene inactivation, cyclosporin A inhibition and cDNA
arrays approaches in the phytopathogenic fungus Botrytis cinerea. Mol Microbiol 50, 1451-
1465.
Weissenmayer, B., Boeckeler, K., Lahrz, A., and Mutzel, R. (2005). The calcineurin inhibitor
gossypol impairs growth, cell signalling and development in
Dictyostelium
discoideum. FEMS
Microbiol Lett 242, 19-25.
Winslow, M.M., Pan, M., Starbuck, M., Gallo, E.M., Deng, L., Karsenty, G., and Crabtree, G.R.
(2006). Calcineurin/NFAT signaling in osteoblasts regulates bone mass. Dev Cell 10, 771-782.
Wu, H.Y., Hudry, E., Hashimoto, T., Kuchibhotla, K., Rozkalne, A., Fan, Z., Spires-Jones, T., Xie,
H., Arbel-Ornath, M., Grosskreutz, C.L., Bacskai, B.J., and Hyman, B.T. (2010a). Amyloid beta
induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and
neuritic dystrophies through calcineurin activation. J Neurosci 30, 2636-2649.
Wu, X., Nguyen, B.C., Dziunycz, P., Chang, S., Brooks, Y., Lefort, K., Hofbauer, G.F., and Dotto,
G.P. (2010b). Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465,
368-372.
Xu, Y.N., Xia, X.X., and Zhong, J.J. (2013). Induced effect of Na(+) on ganoderic acid bio-
synthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction.
Biotechnol Bioeng 110, 1913-1923.
Xu, Y.N., and Zhong, J.J. (2012). Impacts of calcium signal transduction on the fermentation
production of antitumor ganoderic acids by medicinal mushroom Ganoderma lucidum. Bio-
technol Adv 30, 1301-1308.
Yang, J., Zeini, M., Lin, C.Y., Lin, C.J., Xiong, Y., Shang, C., Han, P., Li, W., Quertermous, T., Zhou,
B., and Chang, C.P. (2014). Epicardial calcineurin-NFAT signals through Smad2 to direct coro-
nary smooth muscle cell and arterial wall development. Cardiovasc Res 101, 120-129.
Yoshida, T., Toda, T., and Yanagida, M. (1994). A calcineurin-like gene ppb1+ in fission yeast:
mutant defects in cytokinesis, cell polarity, mating and spindle pole body positioning. J Cell
Sci 107 ( Pt 7), 1725-1735.
Zhang, B.W., Zimmer, G., Chen, J., Ladd, D., Li, E., Alt, F.W., Wiederrecht, G., Cryan, J., O'Neill,
E.A., Seidman, C.E., Abbas, A.K., and Seidman, J.G. (1996). T cell responses in calcineurin A
alpha-deficient mice. J Exp Med 183, 413-420.
Zhang, J., Silao, F.G., Bigol, U.G., Bungay, A.A., Nicolas, M.G., Heitman, J., and Chen, Y.L. (2012).
Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida
lusitaniae. PLoS One 7, e44192.
