Cell News 4/2014
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Brumby AM, Goulding KR, Schlosser T, Loi S, Galea R, Khoo P, Bolden JE, Aigaki T, Humbert
PO, Richardson HE (2011) Identification of novel Ras-cooperating oncogenes in Drosophila
melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Ge-
netics 188:105–25. doi: 10.1534/genetics.111.127910
Burnworth B, Popp S, Stark H-J, Steinkraus V, Bröcker EB, Hartschuh W, Birek C, Boukamp P
(2006) Gain of 11q/cyclin D1 overexpression is an essential early step in skin cancer deve-
lopment and causes abnormal tissue organization and differentiation. Oncogene 25:4399–
412. doi: 10.1038/sj.onc.1209474
Checkley LA, Rho O, Angel JM, Cho J, Blando J, Beltran L, Hursting S, Digiovanni J (2013)
Metformin Inhibits Skin Tumor Promotion in Overweight and Obese Mice. Cancer Prev Res
(Phila). doi: 10.1158/1940-6207.CAPR-13-0110
Ellenbroek SIJ, Iden S, Collard JG (2012) Cell polarity proteins and cancer. Semin Cancer Biol
22:208–215. doi: 10.1016/j.semcancer.2012.02.012
Galvez AS, Duran A, Linares JF, Pathrose P, Castilla E a, Abu-Baker S, Leitges M, Diaz-Meco
MT, Moscat J (2009) Protein kinase Czeta represses the interleukin-6 promoter and impairs
tumorigenesis in vivo. Mol Cell Biol 29:104–15. doi: 10.1128/MCB.01294-08
Godde NJ, Sheridan JM, Smith LK, Pearson HB, Britt KL, Galea RC, Yates LL, Visvader JE,
Humbert PO (2014) Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and
ductal integrity and suppress tumour formation in the mammary gland. PLoS Genet
10:e1004323. doi: 10.1371/journal.pgen.1004323
Goulas S, Conder R, Knoblich JA (2012) The Par Complex and Integrins Direct Asymmet-
ric Cell Division in Adult Intestinal Stem Cells. Cell Stem Cell 11:529–540. doi: 10.1016/j.
stem.2012.06.017
Gunaratne A, Thai BL, Di Guglielmo GM (2013) Atypical protein kinase C phosphorylates
Par6 and facilitates transforming growth factor β-induced epithelial-to-mesenchymal tran-
sition. Mol Cell Biol 33:874–86. doi: 10.1128/MCB.00837-12
Hanahan D, Weinberg RA, Francisco S (2000) The Hallmarks of Cancer Review University of
California at San Francisco. 100:57–70.
Huang L, Muthuswamy SK Polarity protein alterations in carcinoma : a focus on emerging
roles for polarity regulators. doi: 10.1016/j.gde.2009.12.001
Humbert PO, Grzeschik N a, Brumby a M, Galea R, Elsum I, Richardson HE (2008) Control
of tumourigenesis by the Scribble/Dlg/Lgl polarity module. Oncogene 27:6888–907. doi:
10.1038/onc.2008.341
Iden S, Collard JG (2008) Crosstalk between small GTPases and polarity proteins in cell
polarization. Nat Rev Mol Cell Biol 9:846–59. doi: 10.1038/nrm2521
Iden S, Misselwitz S, Peddibhotla SSD, Tuncay H, Rehder D, Gerke V, Robenek H, Suzuki A,
Ebnet K (2012a) aPKC phosphorylates JAM-A at Ser285 to promote cell contact maturation
and tight junction formation. J Cell Biol 196:623–39. doi: 10.1083/jcb.201104143
Iden S, van Riel WE, Schäfer R, Song J-Y, Hirose T, Ohno S, Collard JG (2012b) Tumor Type-
Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis. Cancer Cell 22:389–
403. doi: 10.1016/j.ccr.2012.08.004
Jan Y-J, Ko B-S, Liu T-A, Wu Y-M, Liang S-M, Chen S-C, Wang J, Liou J-Y (2013) Expression
of partitioning defective 3 (par-3) for predicting extrahepatic metastasis and survival with
hepatocellular carcinoma. Int J Mol Sci 14:1684–97. doi: 10.3390/ijms14011684
Kemphues K (2000) Minireview. 101:345–348.
Kemphues KJ, Priess JR, Morton DG, Cheng N (1988) Identification of Genes Required for
Cytoplasmic Localization in Early C , elegans Embryos. 52:311–320.
Knust E (1994). Control of epithelial cell polarity in Drosophila. Trends Genet. Aug;10(8):275-
80.
Koster MI (2010) NIH Public Access. 7–10. doi: 10.1111/j.1749-6632.2009.04363.x.Making
Liu S-G, Wang B-S, Jiang Y-Y, Zhang T-T, Shi Z-Z, Yang Y, Yang Y-L, Wang X-C, Lin D-C,
Zhang Y, Yang H, Cai Y, Zhan Q-M, Wang M-R (2011) Atypical protein kinase C
ι
(PKC
ι
)
promotes metastasis of esophageal squamous cell carcinoma by enhancing resistance to
Anoikis via PKCι-SKP2-AKT pathway. Mol Cancer Res 9:390–402. doi: 10.1158/1541-7786.
MCR-10-0359
Liu X, Wang L, Shen Y, Long S, Wan H, Yang P (2013) Disruption of precise regulation of
α
PKC expression and cellular localization is associated with cervical cancer progression.
Arch Gynecol Obstet 288:401–8. doi: 10.1007/s00404-013-2770-7
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A,
Medvedovic M, Brill LM, Plas DR, Riedl SJ, Leitges M, Diaz-Meco MT, Richardson AD, Moscat
J (2013) Control of Nutrient Stress-Induced Metabolic Reprogramming by PKC
ζ
in Tumori-
genesis. Cell 152:599–611. doi: 10.1016/j.cell.2012.12.028
Mansfield AS, Fields AP, Jatoi A, Qi Y, Adjei A a, Erlichman C, Molina JR (2013) Phase I
dose escalation study of the PKC
ι
inhibitor aurothiomalate for advanced non-small-cell
lung cancer, ovarian cancer, and pancreatic cancer. Anticancer Drugs 1–5. doi: 10.1097/
CAD.0000000000000009
Martin-Belmonte F, Perez-Moreno M (2012) Epithelial cell polarity, stem cells and cancer.
Nat Rev Cancer 12:23–38. doi: 10.1038/nrc3169
McCaffrey LM, Macara IG (2009) The Par3/aPKC interaction is essential for end bud remo-
deling and progenitor differentiation during mammary gland morphogenesis. Genes Dev
23:1450–60. doi: 10.1101/gad.1795909
McCaffrey LM, Montalbano J, Mihai C, Macara IG (2012) Loss of the Par3 polarity prote-
in promotes breast tumorigenesis and metastasis. Cancer Cell 22:601–14. doi: 10.1016/j.
ccr.2012.10.003
McClatchey AI, Yap AS (2012) Contact inhibition (of proliferation) redux. Curr Opin Cell Biol
24:685–94. doi: 10.1016/j.ceb.2012.06.009
Murray NR, Kalari KR, Fields AP (2011) Protein kinase C
ι
expression and oncogenic signaling
mechanisms in cancer. J Cell Physiol 226:879–87. doi: 10.1002/jcp.22463
Murray NR, Weems J, Braun U, Leitges M, Fields AP (2009) Protein kinase C betaII and
PKCiota/lambda: collaborating partners in colon cancer promotion and progression. Cancer
Res 69:656–62. doi: 10.1158/0008-5472.CAN-08-3001
Niessen MT, Iden S, Niessen CM (2012) The in vivo function of mammalian cell and tis-
sue polarity regulators - how to shape and maintain the epidermal barrier. J Cell Sci. doi:
10.1242/jcs.092890
Niessen MT, Scott J, Zielinski JG, Vorhagen S, Sotiropoulou P a., Blanpain C, Leitges M, Nies-
sen CM (2013) aPKC controls epidermal homeostasis and stem cell fate through regulation
of division orientation. J Cell Biol 1–14. doi: 10.1083/jcb.201307001
Oberholzer P a, Kee D, Dziunycz P, Sucker A, Kamsukom N, Jones R, Roden C, Chalk CJ,
Ardlie K, Palescandolo E, Piris A, MacConaill LE, Robert C, Hofbauer GFL, McArthur G a,
Schadendorf D, Garraway L a (2012) RAS mutations are associated with the development
of cutaneous squamous cell tumors in patients treated with RAF inhibitors. J Clin Oncol
30:316–21. doi: 10.1200/JCO.2011.36.7680
Paget J a, Restall IJ, Daneshmand M, Mersereau J a, Simard M a, Parolin D a E, Lavictoire
SJ, Amin MS, Islam S, Lorimer I a J (2012) Repression of cancer cell senescence by PKCι.
Oncogene 31:3584–96. doi: 10.1038/onc.2011.524
Pagliarini R a, Xu T (2003) A genetic screen in Drosophila for metastatic behavior. Science
302:1227–31. doi: 10.1126/science.1088474
Pearson HB, Perez-mancera PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield
A, Tuveson DA, Simon R, Humbert PO (2011) SCRIB expression is deregulated in human
prostate cancer , and its deficiency in mice promotes prostate neoplasia. 121:4257–4267.
doi: 10.1172/JCI58509DS1
Perez-Losada J, Balmain A (2003) Stem-cell hierarchy in skin cancer. Nat Rev Cancer 3:434–
43. doi: 10.1038/nrc1095
Regala RP, Davis RK, Kunz A, Khoor A, Leitges M, Fields AP (2009) Atypical protein kinase
C{iota} is required for bronchioalveolar stem cell expansion and lung tumorigenesis. Can-
cer Res 69:7603–11. doi: 10.1158/0008-5472.CAN-09-2066
Rimessi A, Zecchini E, Siviero R, Giorgi C, Leo S, Rizzuto R, Pinton P (2012) The selective
inhibition of nuclear PKC
ζ
restores the effectiveness of chemotherapeutic agents in che-
moresistant cells © 2012 Landes Bioscience .
Ben Sahra I, Le Marchand-Brustel Y, Tanti J-F, Bost F (2010) Metformin in cancer the-
rapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 9:1092–9. doi:
10.1158/1535-7163.MCT-09-1186
Scotti ML, Bamlet WR, Smyrk TC, Fields AP, Murray NR (2010) Protein kinase Ciota is requi-
red for pancreatic cancer cell transformed growth and tumorigenesis. Cancer Res 70:2064–
74. doi: 10.1158/0008-5472.CAN-09-2684
Tepass U (2012) The apical polarity protein network in Drosophila epithelial cells: regulation
of polarity, junctions, morphogenesis, cell growth, and survival. Annu Rev Cell Dev Biol
28:655–85. doi: 10.1146/annurev-cellbio-092910-154033
Watt FM, Jensen KB (2009) Epidermal stem cell diversity and quiescence. EMBO Mol Med
1:260–7. doi: 10.1002/emmm.200900033
Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK (2013) Loss of Par3 promotes breast
cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol 15:189–200. doi:
10.1038/ncb2663
Yoshida K, Yokouchi M, Nagao K, Ishii K, Amagai M, Kubo A (2013) Functional tight junction
barrier localizes in the second layer of the stratum granulosum of human epidermis. J Der-
matol Sci 71:89–99. doi: 10.1016/j.jdermsci.2013.04.021
Yoshihama Y, Izumisawa Y, Akimoto K, Satoh Y, Mizushima T, Satoh K, Chida K, Takagawa
R, Akiyama H, Ichikawa Y, Kunisaki C, Inayama Y, Endo I, Nagashima Y, Ohno S (2013) High
expression of KIBRA in low atypical protein kinase C-expressing gastric cancer correlates
with lymphatic invasion and poor prognosis. Cancer Sci 104:259–65. doi: 10.1111/cas.12066
Young J, Valencia T, Abu-baker S, Linares J, Jun S, Yajima T, Chen J (2013) c-Myc phospho-
rylation by PKC
ζ
represses prostate tumorigenesis. 1–6. doi: 10.1073/pnas.1221799110/-/
DCSupplemental.www.pnas.org/cgi/doi/10.1073/pnas.1221799110
Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK (2008)
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell pola-
rity in carcinoma. Cell 135:865–78. doi: 10.1016/j.cell.2008.09.045
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