Cell News | Issue 01, 2014 - page 21

cartilage in vivo and in vitro. Nature 434: 648-652
Suleman F, Gualeni B, Gregson HJ, Leighton MP, Piróg KA, Edwards S, Holden P, Boot-Hand-
ford RP, Briggs MD. 2012. A novel form of chondrocyte stress is triggered by a COMP muta-
tion causing pseudoachondroplasia. Hum Mutat 33: 218-231
Svensson L, Aszodi A, Heinegard D, Hunziker EB, Reinholt FP, Fassler R, Oldberg A. 2002.
Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol
Cell Biol 22: 4366-4371
Thur J, Rosenberg K, Nitsche DP, Pihlajamaa T, Ala-Kokko L, Heinegård D, Paulsson M, Maurer
P. 2001. Mutations in cartilage oligomeric matrix protein (COMP) causing pseudoachondro-
plasia and multiple epiphyseal dysplasia affect binding of calcium and collagen I, II, and IX.
J Biol Chem 276: 6083-6092
van der Weyden L, Wei L, Luo J, Yang X, Birk DE, Adams DJ, Bradley A, Chen Q. 2006. Func-
tional knockout of the matrilin-3 gene causes premature chondrocyte maturation to hy-
pertrophy and increases bone mineral density and osteoarthritis. Am J Pathol 169: 515-527
Vaughan L, Mendler M, Huber S, Bruckner P, Winterhalter KH, Irwin MI, Mayne R. 1988.
D-periodic distribution of collagen type IX along cartilage fibrils. J Cell Biol 106: 991-997
Vincourt JB, Gillet P, Rat AC, Guillemin F, Netter P, Mainard D, Magdalou J. 2012. Measure-
ment of matrilin-3 levels in human serum and synovial fluid using a competitive enzyme-
linked immunosorbent assay. Osteoarthritis Cartilage 20: 783-786
Vincourt JB, Vignaud JM, Lionneton F, Sirveaux F, Kawaki H, Marchal S, Lomazzi S, Plénat F,
Guillemin F, Netter P, Takigawa M, Mainard D, Magdalou J. 2008. Increased expression of
matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors,
and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.
Arthritis Rheum 58: 2798-2808
Warman ML, Cormier-Daire V, Hall C, Krakow D, Lachman R, LeMerrer M, Mortier G, Mundlos
S, Nishimura G, Rimoin DL, Robertson S, Savarirayan R, Sillence D, Spranger J, Unger S, Zabel
B, Superti-Furga A. 2011. Nosology and classification of genetic skeletal disorders: 2010
revision. Am J Med Genet A. 155: 943-968
Wiberg C, Klatt AR, Wagener R, Paulsson M, Bateman JF, Heinegard D, Mörgelin M. 2003.
Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both
collagen II and aggrecan. J Biol Chem 278: 37698-37704
About the author
Frank Zaucke studied Biology at the
University of Karlsruhe. He then did
his PhD with Harald F. Krug in the
Institute for Genetics and Toxicology
at the Karlsruhe Institute of Techno-
logy (KIT) where he worked on the
effect of organometallic compounds
on cells with special regard on sig-
nal transduction and apoptosis. For
his postdoc, he went to the Center
for Biochemistry at the Medical Fa-
culty, University of Cologne, where
he started to focus on the extracellular matrix with Mats Pauls-
son and studied chondrocyte differentiation. After a couple of
years he became an independent group leader at the same insti-
tute. In 2010, he obtained his Venia legendi in Biochemistry and
Molecular Biology. The main research interest of his group is to
elucidate the molecular and cellular basis of extracellular matrix
assembly and to define the contribution of extracellular matrix
components to tissue function and connective tissue pathologies
with special regard to cartilage and bone.
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