17816-17821.
Lin WC, Davenport CM, Mourot A, Vytla D, Smith CM, Medeiros KA, Chambers JJ, Kramer
RH (2014). Engineering a light-regulated GABAA receptor for optical control of neural
inhibition. ACS Chem Biol 9, 1414-1419.
Miesenböck G (2009). The optogenetic catechism. Science 326, 395-399.
Miesenböck G (2011). Optogenetic control of cells and circuits. Annu Rev Cell Dev Biol
27, 731-758.
Möglich A, Moffat K (2010). Engineered photoreceptors as novel optogenetic tools. Photo-
chem Photobiol Sci 9, 1286-1300.
Nagel G, Szellas T, Huhn W, Kateriya S, Adeishvili N, Berthold P, Ollig D, Hegemann P,
Bamberg E (2003). Channelrhodopsin-2, a directly light-gated cation-selective membrane
channel. Proc Natl Acad Sci USA 100, 13940-13945.
Niswender CM, Conn PJ (2010). Metabotropic glutamate receptors: physiology, pharmaco-
logy, and disease. Ann Rev Pharm Tox 50, 295-322.
Reiner A, Arant RJ, Isacoff EY (2012). Assembly stoichiometry of the GluK2/GluK5 kainate
receptor complex. Cell Rep 1, 234-240.
Reiner A, Isacoff EY (2013). The Brain Prize 2013: the optogenetics revolution. Trends
Neurosci 36, 557-560.
Reiner A, Isacoff EY (2014a). Photoswitching of cell surface receptors using tethered ligan-
ds. Meth Mol Biol 1148, 45-68.
Reiner A, Isacoff EY (2014b). Tethered ligands reveal glutamate receptor desensitization
depends on subunit occupancy. Nat Chem Biol 10, 273-280.
Sandoz G, Levitz J (2013). Optogenetic techniques for the study of native potassium chan-
nels. Front Mol Neurosci 6, 6.
Schröder-Lang S, Schwärzel M, Seifert R, Strünker T, Kateriya S, Looser J, Watanabe M,
Kaupp UB, Hegemann P, Nagel G (2007). Fast manipulation of cellular cAMP level by light
in vivo. Nat Meth 4, 39-42.
Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf
M, Numano R, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff EY
(2007). Remote control of neuronal activity with a light-gated glutamate receptor. Neuron
54, 535-545.
Tochitsky I, Banghart MR, Mourot A, Yao JZ, Gaub B, Kramer RH, Trauner D (2012). Op-
tochemical control of genetically engineered neuronal nicotinic acetylcholine receptors.
Nat Chem 4, 105-111.
Traynelis SF, Wollmuth LP, McBain CJ, Menniti FS, Vance KM, Ogden KK, Hansen KB, Yuan
H, Myers SJ, Dingledine R (2010). Glutamate receptor ion channels: structure, regulation,
and function. Pharm Rev 62, 405-496.
Tye KM, Deisseroth K (2012). Optogenetic investigation of neural circuits underlying brain
disease in animal models. Nat Rev Neurosci 13, 251-266.
Volgraf M, Gorostiza P, Numano R, Kramer RH, Isacoff EY, Trauner D (2006). Allosteric con-
trol of an ionotropic glutamate receptor with an optical switch. Nat Chem Biol 2, 47-52.
Wyart C, Del Bene F, Warp E, Scott EK, Trauner D, Baier H, Isacoff EY (2009). Optogenetic
dissection of a behavioural module in the vertebrate spinal cord. Nature 461, 407-410.
Zemelman BV, Lee GA, Ng M, Miesenböck G (2002). Selective photostimulation of geneti-
cally chARGed neurons. Neuron 33, 15-22.
Zhang F, Vierock J, Yizhar O, Fenno LE, Tsunoda S, Kianianmomeni A, Prigge M, Berndt A,
Cushman J, Polle J, Magnuson J, Hegemann P, Deisseroth K (2011). The microbial opsin
family of optogenetic tools. Cell 147, 1446-1457.
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