improvement of osteogenesis in elderly people.
        
        
          
            About the author
          
        
        
          Anjali P. Kusumbe (PhD)
        
        
          Max Planck Institute for Molecular Biomedicine
        
        
          Roentgenstrasse 20, 48149 Muenster, Germany
        
        
          E-mail: 
        
        
        
          03/2012 to Present: Postdoctoral fellow
        
        
          Max Planck Institute for Molecular Biomedicine
        
        
          Muenster, Germany
        
        
          07/2005 – 01/2012: PhD student
        
        
          National Center for Cell Science (NCCS), Pune, India
        
        
          Department of Biotechnology (DBT), Government of India
        
        
          Award of PhD degree (01/2013)
        
        
          08/2004 - 06/2005: Junior Research Fellow
        
        
          Indian Institute of Science, Bangaluru, India
        
        
          08/2002 - 04/2004: Master of Science; Biotechnology
        
        
          Hislop School of Biotechnology, Nagpur University, India
        
        
          07/1999 - 07/2002: Bachelor of Science
        
        
          Institute of Science, Nagpur University, India
        
        
          
            Acknowledgements
          
        
        
          I express my sincere gratitude to Prof. Dr. Ralf H. Adams for his
        
        
          invaluable scientific inputs and constant support. I am grateful
        
        
          to Saravana K. Ramasamy for his contribution to this work (equal
        
        
          contribution). Finally, I would like to thank all the members of
        
        
          Adams department.
        
        
          
            References
          
        
        
          1. Maes, C. et al. Increased skeletal VEGF enhances beta-catenin activity and results in ex-
        
        
          cessively ossified bones. EMBO J 29, 424-441 (2010).
        
        
          2. Glowacki, J. Angiogenesis in fracture repair. Clin. Orthop. Relat. Res. S82-89 (1998).
        
        
          3. Burkhardt, R. et al. Changes in trabecular bone, hematopoiesis and bone marrow vessels in
        
        
          aplastic anemia, primary osteoporosis, and old age: a comparative histomorphometric study.
        
        
          Bone 8, 157-164 (1987).
        
        
          4. Lu, C. et al. Effect of age on vascularization during fracture repair. J. Orthop. Res. 26,
        
        
          1384-1389 (2008).
        
        
          5. Wang, Y. et al. Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis.
        
        
          Nature 465, 483-486 (2010).
        
        
          6. Muzumdar, M. D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global double-fluorescent Cre
        
        
          reporter mouse. Genesis 45, 593-605 (2007).
        
        
          7. Nakashima, K. et al. The novel zinc finger-containing transcription factor osterix is requi-
        
        
          red for osteoblast differentiation and bone formation. Cell 108, 17-29 (2002).
        
        
          8. Lips, P., Courpron, P. & Meunier, P. J. Mean wall thickness of trabecular bone packets in the
        
        
          human iliac crest: changes with age. Calcif. Tissue Res. 26, 13-17 (1978).
        
        
          9. Pugh, C. W. & Ratcliffe, P. J. Regulation of angiogenesis by hypoxia: role of the HIF system.
        
        
          Nat. Med. 9, 677-684 (2003).
        
        
          10. Tang, N. et al. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF
        
        
          autocrine loop necessary for tumorigenesis. Cancer Cell 6, 485-495 (2004).
        
        
          11. Tanimoto, K., Makino, Y., Pereira, T. & Poellinger, L. Mechanism of regulation of the hy-
        
        
          poxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein. EMBO J
        
        
          19, 4298-4309 (2000).
        
        
          12. Jones, D. T. & Harris, A. L. Identification of novel small-molecule inhibitors of hypoxia-
        
        
          inducible factor-1 transactivation and DNA binding. Mol. Cancer Ther. 5, 2193-2202 (2006).
        
        
          13. Wang, L. et al. Identification of a clonally expanding haematopoietic compartment in
        
        
          bone marrow. EMBO J 32, 219-230 (2013).
        
        
          14. Ramasamy, S. K., Kusumbe, A. P., & Adams, R. H. Endothelial notch activity promotes
        
        
          angiogenesis and osteogenesis in bone. Nature 507, 376-380 (2014).
        
        
          15. Losordo, D. W. & Isner, J. M. Estrogen and angiogenesis: A review. Arterioscler. Thromb.
        
        
          Vasc. Biol. 27, 255-65 (2001).
        
        
          See like you have
        
        
          never seen before
        
        
          Nikon GmbH - Tiefenbroicher Weg 25 - 40472 Düsseldorf - Germany
        
        
          Tel.: 0211/9414 214 - Fax: 0211/9414 322 - E-Mail:
        
        
        
        
          Ÿ
        
        
          Zoomweltmeister 25:1
        
        
          Ÿ
        
        
          Sensationelle Auflösung: 1100 LP/mm
        
        
          Ÿ
        
        
          Vollständige Ergonomie
        
        
          Ÿ
        
        
          Stark verbesserte Fluoreszenz
        
        
          Ÿ
        
        
          Hellere Bilder und höherer Kontrast