Cell News 04/2019
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that centrosomal MT dynamics are enhanced, most likely in
tumor cells undergoing metastasis-directed EMT. The use of
anti-mitotic drugs that target MTs (e.g. taxenes and vinca alka-
loids) has proven successful in oncology, yet very often tumors
develop resistance to the drugs. Although the reason for this is
rather far from being understood, pilot observations indicate
that adaptations in MT dynamics (so far mostly by altering
the protein levels of Tubulin variants) may play an important
role. Our discoveries not only support these observations but
also offer knowledge about the possible cellular and molecular
mechanism by which cancer cells resist treatment.
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