Cell News 04/2019
21
PRIZE WINNERS 2019
12/2018:
'Researcher of the Year'
, Cambridge Independent
Science and Technology Awards. (Highly Commended)
11/2018:
EMBO Young Investigator Award.
09/2018:
Dame Sheila Sherlock Prize 2018.
The British Associa-
tion for the Study of the Liver (BASL).
12/2017:
The Women in Cell Biology Early Career Medal for 2018
The British Society for Cell Biology. “for pionerring research on
stem cell, in particular the work on liver organoids”
12/2016: T
he Hamdan Award for Medical Research Excellence
Hamdan Awards. “for innovative methods and research that
resulted in novel discoveries and inventions”
09/2014:
Wellcome-Beit Prize
Wellcome Trust. “for outstanding
scientists of the 2014 year
02/2014:
2014 NC3Rs International Prize.
National Centre for the
Replacement, Refinement & Reduction of Animals in Research.
UK. For growing “mini-livers” in culture
PUBLICATION LIST
Below there is a selection of the 10 most important manuscripts:
1. Luigi Aloia, Mikel Alexander McKie, Grégoire Vernaz, Lucía
Cordero-Espinoza, Niya Aleksieva, Jelle van den Ameele, Fran-
cesco Antonica, Berta Font-Cunill, Alexander Raven, Riccardo
Aiese Cigliano, German Belenguer, Richard L. Mort, Andrea
H. Brand, Magdalena Zernicka-Goetz, Stuart J. Forbes, Eric A.
Miska,
$
Meritxell Huch
Epigenetic remodelling licences adult
cholangiocytes for organoid formation and liver regeneration
Nature Cell Biology
(2019) Nov 4. doi: 10.1038/s41556-019-
0402-6. PMID: 31685987
2. Prior N, Hindley CJ, Rost F, Meléndez E, Lau WWY, Göttgens
B, Rulands S, Simons BD,
$
Huch M.
Lgr5+ stem and progen-
itor cells reside at the apex of a heterogeneous embryonic
hepatoblast pool.
Development
. (2019) Jun 12;146(12). pii:
dev174557. doi: 10.1242/dev.174557. PMID: 31142540
3. Broutier L, Mastrogiovanni G, Verstegen MM, Francies HE, Ga-
varró LM, Bradshaw CR, Allen GE, Arnes-Benito R, Sidorova O,
Gaspersz MP, Georgakopoulos N, Koo BK, Dietmann S, Davies
SE, Praseedom RK, Lieshout R, IJzermans JNM, Wigmore SJ,
Saeb-Parsy K, Garnett MJ, van der Laan LJ,
$
Huch M
. Tu-
mour-derived Organoid Cultures model Primary Human Liver
Cancer in vitro.
Nature Medicine
(2017) Dec;23(12):1424-
1435. doi: 10.1038/nm.4438. PMID: 29131160
4.
$
Huch M
, Knoblich JA, Lutolf MP, Martinez-Arias A. The hope
and the hype of organoid research.
Development
. (2017) Mar
15;144(6):938-941. PMID: 28292837
5: Broutier L, Andersson-Rolf A, Hindley CJ, Boj SF, Clevers H,
Koo BK,
$
Huch M
. Culture and establishment of self-renew-
ing human and mouse adult liver and pancreas 3D organoids
and their genetic manipulation.
Nature Protocols
(2016) Sep;
11(9): 1724-43. PMID: 27560176
$
Huch, M
. and B.K. Koo Modeling mouse and human develop-
ment using organoid cultures.
Development
(2015) 142(18):
3113-3125. PMID: 26395140
7.
$
Huch M
, Gehart H, van Boxtel R, Hamer K, Blokzijl F, Verste-
gen MM, Ellis E, van Wenum M, Fuchs SA, de Ligt J, van de
Wetering M, Sasaki N, Boers SJ, Kemperman H, de Jonge J,
Ijzermans JN, Nieuwenhuis EE, Hoekstra R, Strom S, Vries RR,
van der Laan LJ, Cuppen E, Clevers H. Long-Term Culture of
Genome-Stable Bipotent Stem Cells from Adult Human Liver.
Cell
(2015) Jan 15;160(1-2):299-312. PMID: 25533785
8.
Huch M*
, Bonfanti P*, Boj SF*, Sato T*, Loomans CJ, van de
Wetering M, Sojoodi M, Li VS, Schuijers J, Gracanin A, Ring-
nalda F, Begthel H, Hamer K, Mulder J, van Es JH, de Koning E,
Vries RG, Heimberg H, Clevers H. Unlimited in vitro expansion
of adult bi-potent pancreas progenitors through the Lgr5/R-
spondin axis.
EMBO Journal
(2013) Oct 16;32(20):2708-21.
PMID: 24045232
9.
Huch M
, Dorrell C, Boj SF, van Es JH, Li VSW, van de Wetering
M, Sato T, Hamer K, Sasaki N, Finegold MJ, Haft A, Vries R,
Grompe M, Clevers H. In vitro expansion of single Lgr5+ liver
stem cells induced by Wnt-driven regeneration.
Nature
(2013)
Feb 14;494: 247-50. PMID: 23354049
10. Barker N*,
Huch M
*, Kujala P, van de Wetering M, Snippert
HJ, van Es JH, Sato T, Stange DE, Begthel H, van den Born M,
Danenberg E, van den Brink S, Korving J, Abo A, Peters PJ,
Wright N, Poulsom R, Clevers H. Lgr5(+ve) stem cells drive
self-renewal in the stomach and build long-lived gastric
units
in vitro. Cell Stem Cell
(2010) Jan 8;6(1):25-36. PMID:
20085740
Prof. Dr. Carien Niessen (DGZ Vice President), Prof. Dr. Oliver Gruss
(DGZ President), prize winner Dr. Meritxell Huch, Achim Schwörer
(BINDER GmbH).
