Cell News 04/2019
20
PRIZE WINNERS 2019
10 Prior N, Hindley CJ, Rost F, et al. Lgr5+ stem/progenitor cells
reside at the apex of a heterogeneous embryonic hepatoblast
pool.
Development
2019;
146
: dev174557. doi: 10.1242/
dev.174557
11 Duncan AW, Dorrell C, Grompe M. Stem cells and liver regen-
eration.
Gastroenterology
2009;
137
:466-81. doi: 10.1053/j.
gastro.2009.05.044.
12 Ober EA, Lemaigre FP. Development of the liver: Insights into
organ and tissue morphogenesis.
J. Hepatol.
2018;
68
:1049–
62. doi:10.1016/j.jhep.2018.01.005
13 Zorn. Liver Development.
StemBook
Published Online First:
2008. doi:10.3824/stembook.1.25.1
14 Magami Y, Azuma T, Inokuchi H, et al. Cell proliferation and
renewal of normal hepatocytes and bile duct cells in adult
mouse liver.
Liver Int
2002;
22
:419–25. doi:10.1034/j.1600-
0676.2002.01702.x
15 Malato Y, Naqvi S, Schürmann N, et al. Fate tracing of ma-
ture hepatocytes in mouse liver homeostasis and regenera-
tion.
J Clin Invest
2011;
121
:4850–60. doi:10.1172/JCI59261
16 Wang B, Zhao L, Fish M, et al. Self-renewing diploid
Axin2+ cells fuel homeostatic renewal of the liver.
Nature
2015;
524
:180–5. doi:10.1038/nature14863
17 Cordero-Espinoza L, Huch M. The balancing act of the
liver: tissue regeneration versus fibrosis.
J. Clin. Invest.
2018;
128
:85–96. doi:10.1172/JCI93562
18 Michalopoulos GK, DeFrances MC. Liver regeneration.
Science
1997;
276
:60–6. doi:10.1126/SCIENCE.276.5309.60
19 Kang L-I, Mars WM, Michalopoulos GK. Signals and Cells
Involved in Regulating Liver Regeneration.
Cells
2012;
1
:1261.
doi:10.3390/CELLS1041261
20 Choi T, Ninov N, Stainier DYR, et al. Extensive Conversion
of Hepatic Biliary Epithelial Cells to Hepatocytes After Near
Total Loss of Hepatocytes in Zebrafish.
Gastroenterology
2014;
146
:776–88. doi:10.1053/J.GASTRO.2013.10.019
21 Raven A, Lu W-Y, Man TY, et al. Cholangiocytes act as facul-
tative liver stem cells during impaired hepatocyte regenera-
tion.
Nature
2017;
547
:350–4. doi:10.1038/nature23015
22 Deng X, Zhang X, Li W, et al. Chronic Liver Injury Induc-
es Conversion of Biliary Epithelial Cells into Hepato-
cytes.
Cell Stem Cell
2018;
23
:114-122.e3. doi:10.1016/J.
STEM.2018.05.022
23 Russell JO, Lu W-Y, Okabe H, et al. Hepatocyte-Specific
β
-Catenin Deletion During Severe Liver Injury Provokes
Cholangiocytes to Differentiate Into Hepatocytes.
Hepatology
2019;
69
:742–59. doi:10.1002/hep.30270
24 Michalopoulos GK, Bowen WC, Mulè K, et al. Histological
Organization in Hepatocyte Organoid Cultures.
Am J Pathol
2001;
159
:1877–87. doi:10.1016/S0002-9440(10)63034-9
25 Peng WC, de Lau W, Forneris F, et al.,
Cell Rep
. 2013;
3
:1885-92. doi: 10.1016/j.celrep.2013.06.009.
26 Takase HM, Itoh T, Ino M et al., FGF7 is a functional niche
signal required for stimulation of adult liver progenitor cells
that support liver regeneration.
Genes Dev.
2013;
27
:169-
181. doi: 10.1101/gad.204776.112.
27 Aloia L, McKie MA, Vernaz G, Cordero-Espinoza L, et al.,
Epigenetic remodelling licences adult cholangiocytes for or-
ganoid formation and liver regeneration.
Nat Cell Biol.
2019;
21
:1321-1333.
28 Francis H, Glaser S, Ueno Y, et al., cAMP stimulates the secre-
tory and proliferative capacity of the rat intrahepatic biliary
epithelium through changes in the PKA/Src/MEK/ERK1/2
pathway.
J Hepatol.
2004;
41
:528-37.
29 Blokzijl F, de Ligt J, Jager M, et al., Tissue-specific mutation
accumulation in human adult stem cells during life.
Nature
.
2016;
538
:260-264. doi: 10.1038/nature19768
30 Fagiuoli S, Daina E, D’Antiga L, et al. Monogenic diseas-
es that can be cured by liver transplantation.
J Hepatol
2013;
59
:595–612. doi:10.1016/j.jhep.2013.04.004
31 Stoller JK, Aboussouan LS. Alpha1-antitrypsin deficiency.
Lancet
. 2005;
365
:2225-36
32 Marquardt JU, Andersen JB. Liver cancer oncogenomics:
opportunities and dilemmas for clinical applications.
Hepat
Oncol
2015;
2
:79–93. doi:10.2217/hep.14.24
33 Broutier L, Mastrogiovanni G, Verstegen MM, et al. Human
primary liver cancer–derived organoid cultures for disease
modeling and drug screening.
Nat Med
2017;
23
:1424–35.
doi:10.1038/nm.4438
Curriculum Vitae
Meritxell Huch, PhD
EDUCATION and QUALIFICATIONS
17/07/2007
PhD
Centre for Genom-
ic Regulation-CRG-,
University of Barcelona,
Barcelona, Spain. (Advisor:
Dr Cristina Fillat) Qualifi-
cation: Excellent cum laude
23/09/2003
Master of Advanced Studies
- University of
Barcelona (UB). Qualification: Excellent
25/07/2001
BSc in Pharmaceutical Science
, University of
Barcelona (UB)
Qualification: Excellent. First-Class Honours
(Prize for Outstanding Graduate Student)
RESEARCH EXPERIENCE
06/2019-present:
Lise Meitner Excellence Program Group Lead-
er
, Max Planck Gesellschaft, Max Planck Institute of Molecular
Cell Biology and Genetics (MPI-CBG), Dresden, Germany.
02/2014 – 03/2020:
Group Leader
, The Gurdon Institute,
University of Cambridge-UK.
Affiliated Group Leader
at The Wellcome Trust/MRC Cambridge
Stem Cell Institute
PRIZES & AWARDS
09/2019:
The BINDER Innovation Prize 2019.
German Society for
Cell Biology (DGZ).
